Friday, December 26, 2014

Being pear-shaped carries health risks, too, researchers say

From page A1 | January 16, 2013 |

BigStock photo

It’s all going pear-shaped for the notion that, when it comes to health, being shaped like a pear beats being shaped like an apple.

That’s according to UC Davis researchers, who believe they have partly deflated the commonly held belief that a person with more fat around the abdomen is at greater risk for diabetes and heart disease than those who carry weight lower on their bodies.

The UCD researchers found that gluteal adipose tissues — that’s fat stored in the buttocks — secretes abnormal levels of chemerin and omentin-1: proteins that correlate with other risk factors shown to increase the risk for heart disease and diabetes.

“Fat in the abdomen has long been considered the most detrimental to health, and gluteal fat was thought to protect against diabetes, heart disease and metabolic syndrome,” said Ishwarlal Jialal, lead author of the study published online this month in The Journal of Clinical Endocrinology and Metabolism, in a news release.

“But our research helps to dispel the myth that gluteal fat is ‘innocent.’ ”

Researchers found that in a group of 45 patients with early metabolic syndrome, gluteal fat secreted elevated levels of chemerin and reduced levels of omentin-1 when compared to a control group — independent of the patients’ age, body mass index and waist size.

Metabolic syndrome affects about 35 percent of people ages 20 and over. It refers to risk factors that dramatically increase the risk of heart disease and diabetes. Among them: having a large waistline, high blood pressure and low levels of so-called “good cholesterol.”

Jialal, a professor of pathology and laboratory medicine and of internal medicine, said high chemerin levels show promise as an indicator of metabolic syndrome. They are also an indicator of inflammation and insulin resistance and could perhaps be used to identify high-risk obesity.

“The good news is that with weight loss, you can reduce chemerin levels along with the risk for metabolic syndrome,” Jialal said.

Funded by the American Diabetes Association, the study also drew on work from researchers at Baylor College of Medicine, the University of Texas Southwestern Medical Center and Vanderbilt University.



Cory Golden

Cory Golden

The Enterprise's higher-education and congressional reporter.
  • Recent Posts

  • Enter your email address to subscribe to this newspaper and receive notifications of new articles by email.

  • .


    Pastor has many plans for CA House

    By Jeff Hudson | From Page: A1 | Gallery

    Exchange students bring the world to Davis

    By Anne Ternus-Bellamy | From Page: A1 | Gallery

    Transit survey: 47 percent ride bikes to campus

    By Special to The Enterprise | From Page: A1 | Gallery

    Special holiday gifts

    By Sue Cockrell | From Page: A3

    Woodland-Davis commute bus service expands

    By Enterprise staff | From Page: A3

    Learn fruit tree tips at free class

    By Enterprise staff | From Page: A3

    Davis Bike Club hears about British cycling tour

    By Enterprise staff | From Page: A3

    Pick up a Davis map at Chamber office

    By Enterprise staff | From Page: A3

    Sierra Club calendars on sale Saturday

    By Enterprise staff | From Page: A3

    Explorit: Get a rise out of science

    By Lisa Justice | From Page: A4

    NAMI meeting offers family support

    By Special to The Enterprise | From Page: A6

    Yoga, chanting intro offered

    By Enterprise staff | From Page: A8



    How much for the calling birds?

    By Creators Syndicate | From Page: B5

    Steve Sack cartoon

    By Debbie Davis | From Page: A10

    Many ensured a successful parade

    By Letters to the Editor | From Page: A10

    Thanks for putting food on the table

    By Letters to the Editor | From Page: A10



    Two more for the road for 9-1 Aggie men

    By Bruce Gallaudet | From Page: B1 | Gallery

    Patterson is college football’s top coach

    By The Associated Press | From Page: B1 | Gallery

    Clippers get a win over Golden State

    By The Associated Press | From Page: B1 | Gallery

    NBA roundup: Heat beat Cavs in LeBron’s return to Miami

    By The Associated Press | From Page: B10 | Gallery





    ‘Unbroken': A bit underwhelming

    By Derrick Bang | From Page: A11 | Gallery

    Folk musicians will jam on Jan. 2

    By Enterprise staff | From Page: A11



    Passat: Roomy, affordable sedan with German engineering

    By Ann M. Job | From Page: B3 | Gallery



    James J. Dunning Jr.

    By Special to The Enterprise | From Page: A4

    Floyd W. Fenocchio

    By Special to The Enterprise | From Page: A4



    Comics: Friday, December 26, 2014 (set 2)

    By Creator | From Page: B7

    Comics: Thursday, December 26, 2014 (set 1)

    By Creator | From Page: A9