Thursday, April 17, 2014
YOLO COUNTY NEWS
99 CENTS

Biological link found between diabetes, heart disease

By
From page A4 | October 18, 2013 | Leave Comment

SACRAMENTO — UC Davis researchers have identified for the first time a biological pathway activated when blood sugar levels are abnormally high and causes irregular heartbeats.

That condition — cardiac arrhythmia — is linked with heart failure and sudden cardiac death.

Reported online earlier this month in the journal Nature, the discovery helps explain why diabetes is a significant independent risk factor for heart disease.

“The novel molecular understanding we have uncovered paves the way for new therapeutic strategies that protect the heart health of patients with diabetes,” said Donald Bers, chair of the UCD department of pharmacology and senior author of the study.

While heart disease is common in the general population, the risk is up to four times greater for diabetics, according to the National Institutes of Health. The American Heart Association estimates that at least 65 percent of people with diabetes die from heart disease or stroke.

Through a series of experiments, the UCD team and its collaborators at the Johns Hopkins University School of Medicine showed that the moderate to high blood glucose levels characteristic of diabetes caused a sugar molecule in heart muscle cells to fuse to a specific site on a protein known as CaMKII.

CaMKII has important roles in regulating normal calcium levels, electrical activity and pumping action of the heart, according to Bers.

Its fusion with the sugar molecule, however, led to chronic overactivation of CaMKII and pathological changes in the finely tuned calcium signaling system it controls — triggering full-blown arrhythmias in just a few minutes.

The arrhythmias were prevented by inhibiting CaMKII or its union the sugar molecule.

The research encompassed detailed molecular experiments in rat and human proteins and tissues, calcium imaging in isolated rat heart muscle cells exposed to high glucose and assessing whole heart arrhythmias with optical mapping in isolated hearts and in live diabetic rats.

This allowed Bers and his team to identify the specific site of sugar attachment to CaMKII, along with how that attachment activated CaMKII and caused calcium-dependent arrhythmias.

In an additional experiment, the team found elevated levels of CaMKII modified by the sugar molecule in both hearts and brains of deceased humans who were diagnosed with diabetes. The highest levels were found in the hearts of patients who had both heart failure and diabetes.

Other UCD researchers on the study included lead author Jeffrey Erickson (now with the University of Otago in New Zealand), Laetitia Pereira, Lianguo Wang, Amanda Ferguson, Khanha Dao, Florin Despa (now with the University of Kentucky) and Crystal Ripplinger.

— UC Davis Health News Office

LEAVE A COMMENT

Discussion | No comments

The Davis Enterprise does not necessarily condone the comments here, nor does it review every post. Read our full policy

.

News

Benefit set for local bike legend

By Adrian Glass-Moore | From Page: A1

 
Jury deliberates murder, elder-abuse charges

By Lauren Keene | From Page: A1

 
Davis wins USA Today Best Cycling Town honor

By Dave Ryan | From Page: A1

 
California residents divided on drought solution

By San Francisco Chronicle | From Page: A2

For the record

By Dave Ryan | From Page: A2

 
Three killed in attack on Ukrainian base

By The Associated Press | From Page: A2 | Gallery

State’s health care sign-ups beat projections

By The Associated Press | From Page: A2

 
For the record

By Enterprise staff | From Page: A2

 
Scholar will discuss human trafficking in Friday talk

By Enterprise staff | From Page: A3

 
Downtown post office set to reopen

By Thomas Oide | From Page: B3

Run or walk to prevent child abuse in Yolo County

By Enterprise staff | From Page: B3 | Gallery

 
Nominations sought for charity paint giveaway

By Enterprise staff | From Page: B3

Food Co-op board plans open house

By Enterprise staff | From Page: A4

 
Davis Downtown hosts candidate forum

By Dave Ryan | From Page: A4

Learn more about Google Glass at talk

By Enterprise staff | From Page: A4

 
Per Capita Davis: Now, for some good news

By John Mott-Smith | From Page: A4

Birch Lane hosts 50th anniversary party

By Enterprise staff | From Page: A4

 
Hannah Stein reads poetry at gallery

By Enterprise staff | From Page: A4

Davis Food Co-op to offer free bags on Earth Day

By Enterprise staff | From Page: A4

 
Get in the picture with school board candidate

By Special to The Enterprise | From Page: A4

KDVS hosts on-air fundraiser April 21-27

By Enterprise staff | From Page: A4

 
Tickets on sale for Pence Garden Tour

By Enterprise staff | From Page: A4

Fundraiser planned for Allen’s campaign

By Enterprise staff | From Page: A4

 
Barbecue celebrates winter shelter program

By Special to The Enterprise | From Page: A5

Sign of things to come

By Fred Gladdis | From Page: A8

 
Davis Soroptimists celebrate 60 years

By Special to The Enterprise | From Page: A8

.

Forum

Fancy meeting you here …

By Special to The Enterprise | From Page: B5

 
Expert: Free parking is a myth

By Special to The Enterprise | From Page: A6

Have they really learned?

By Letters to the Editor | From Page: A6

 
A great community effort

By Letters to the Editor | From Page: A6

Public Health Heroes honored

By Letters to the Editor | From Page: A6

 
Tom Meyer cartoon

By Debbie Davis | From Page: A6

Don’t miss a Trokanski dance

By Letters to the Editor | From Page: A6

 
Frank Bruni: The oldest hatred, forever young

By New York Times News Service | From Page: A6

.

Sports

Foster steps down as Lady Blue Devil basketball coach

By Bruce Gallaudet | From Page: B1 | Gallery

 
River Cats’ streak reaches six wins

By Enterprise staff | From Page: B1

Landry evolves into UCD women’s lacrosse leader

By Bruce Gallaudet | From Page: B1 | Gallery

 
Huge inning propels Pleasant Grove past DHS

By Enterprise staff | From Page: B1

Giants edge Dodgers

By The Associated Press | From Page: B1 | Gallery

 
Youth roundup: Martinez, Chan come up big at gymnastics regional

By Enterprise staff | From Page: B2 | Gallery

Kings drop season finale to Suns

By The Associated Press | From Page: B2

 
Angels get past A’s in extras

By The Associated Press | From Page: B8 | Gallery

.

Features

.

Arts

Wineaux: Good deals off the beaten path

By Susan Leonardi | From Page: A7

 
Rockabilly phenom to play at The Palms

By Enterprise staff | From Page: A7

HellaCappella showcases a cappella singing

By Enterprise staff | From Page: A7

 
‘One’ singular sensation to open at DMTC

By Enterprise staff | From Page: A7

25th annual state clay competition exhibit at The Artery

By Enterprise staff | From Page: A7

 
.

Business

.

Obituaries

Tapan Munroe

By Special to The Enterprise | From Page: A4

 
.

Comics

Comics: Thursday, April 17, 2014

By Creator | From Page: B6