Friday, July 25, 2014
YOLO COUNTY NEWS
99 CENTS

Dog research sheds light on neural tube defects

By
From page A1 | July 23, 2013 |

A gene related to neural tube defects in dogs has for the first time been identified by UC Davis and University of Iowa researchers.

The researchers also found evidence that the gene may be an important risk factor for human neural tube defects, which affect more than 300,000 babies born each year around the world, according to the U.S. Centers for Disease Control and Prevention. Neural tube defects, including anencephaly and spina bifida, are caused by the incomplete closure or development of the spine and skull.

The new findings appear in the new issue of the journal PLOS Genetics.

“The cause of neural tube defects is poorly understood but has long been thought to be associated with genetic, nutritional and environmental factors,” said Noa Safra, lead author on the study and a postdoctoral fellow in the laboratory of Professor Danika Bannasch in the UCD School of Veterinary Medicine.

Sofra noted that dogs provide an excellent biomedical model because they receive medical care comparable to what humans receive, share in a home environment and develop naturally occurring diseases that are similar to those found in humans. More specifically, several conditions associated with neural-tube defects are known to occur naturally in dogs.

All DNA samples used in the study were taken from household pets, rather than laboratory animals, Safra said.

She and colleagues carried out genome mapping in four Weimaraner dogs affected by spinal dysraphism, a naturally occurring spinal-cord disorder, and in 96 such dogs that had no neural tube defects.

Spinal dysraphism, previously reported in the Weimaraner breed, causes symptoms that include impaired motor coordination or partial paralysis in the legs, abnormal gait, a crouched stance and abnormal leg or paw reflexes.

Analysis of a specific region on canine chromosome eight led the researchers to a mutation in a gene called NKX2-8, one of a group of genes known as “homeobox genes,” known to be involved with regulatingpatterns of anatomical development in the embryo.

The researchers determined that the NKX2-8 mutation occurred in the Weimaraner breed with a frequency of 1.4 percent  — 14 mutations in every 1,000 dogs.

Additionally, they tested nearly 500 other dogs from six different breeds that had been reported to be clinically affected by neural tube defects, but did not find copies of the NKX2-8 gene mutation among the non-Weimaraner dogs.

“The data indicate that this mutation does not appear as a benign mutation in some breeds, while causing defects in other breeds,” Safra said. “Our results suggest that the NKX2-8 mutation is a ‘private’ mutation in Weimaraners that is not shared with other breeds.”

The researchers say that identification of such a breed-specific gene may help veterinarians diagnose spinal dysraphism in dogs and enable Weimaraner breeders to use DNA screening to select against the mutation when developing their breeding plans.

In an effort to investigate a potential role for the NKX2-8 mutation in cases of neural tube defects in people, the researchers also sequenced 149 unrelated samples from human patients with spina bifida. They found six cases in which the patients carried mutations of the NKX2-8 gene but stress that further studies are needed to confirm whether these mutations are responsible for the diagnosed neural tube defects.

Other researchers from UCD who collaborated on the study were: Danika Bannasch, Miriam Aguilar, Rochelle Coulson, Nicholas Thomas, Peta Hitchens, Peter Dickinson, Karen Verna and Zena Wolf.

— UC Davis News Service

Comments

comments

  • Recent Posts

  • Enter your email address to subscribe to this newspaper and receive notifications of new articles by email.

  • .

    News

    Tech Trekkers boldly go into STEM fields

    By Amy Jiang | From Page: A1 | Gallery

     
    Decoding breast milk secrets reveals clues to lasting health

    By Pat Bailey | From Page: A1 | Gallery

    California climate change policies to hit our pocketbooks

    By San Francisco Chronicle | From Page: A1

     
    Davis braces for six days of scorching heat

    By Enterprise staff | From Page: A1 | Gallery

    Appeals court upholds high-speed rail route

    By The Associated Press | From Page: A2, 1 Comment

     
    Carwash raises funds for funeral expenses

    By Enterprise staff | From Page: A2

     
    Unitarians will host summer camp

    By Enterprise staff | From Page: A3

    Artists, photographers invited to support Yolo Basin Foundation

    By Special to The Enterprise | From Page: A3 | Gallery

     
    Sudwerk’s sales grow, floating on a sea of dry hop lager

    By Elizabeth Case | From Page: A4 | Gallery

     
    Wetlands visitors will see migrating shorebirds

    By Special to The Enterprise | From Page: A6 | Gallery

    ‘Bak2Sac’ free train ride program launched

    By Enterprise staff | From Page: A7

     
    Explorit: Wonderful wetlands right at home

    By Lisa Justice | From Page: A8 | Gallery

    Recycle old paint cans for free

    By Enterprise staff | From Page: A8

     
    Where your gas money goes

    By San Francisco Chronicle | From Page: A12

    Americans, internationals make connections

    By Enterprise staff | From Page: A16

     
    Can you give them a home?

    By Enterprise staff | From Page: A16 | Gallery

    STEAC needs donations of personal care items

    By Enterprise staff | From Page: A16, 1 Comment

     
    .

    Forum

    Trio disagrees on best option

    By Creators Syndicate | From Page: B5

     
    Support these local restaurants

    By Letters to the Editor | From Page: A10

    Let’s get the bench repaired

    By Letters to the Editor | From Page: A10

     
    Tom Meyer cartoon

    By Debbie Davis | From Page: A10

    Predicting climate changes

    By Letters to the Editor | From Page: A10, 1 Comment

     
    Clinton’s book is worth a read

    By Letters to the Editor | From Page: A10, 3 Comments

    Thanks for emergency help

    By Letters to the Editor | From Page: A10

     
    Commenting system to change

    By Debbie Davis | From Page: A10, 32 Comments

     
    .

    Sports

    Hudson solid, Hamels better in Giants’ loss

    By The Associated Press | From Page: B1 | Gallery

     
    Petrovic, Putnam share Canadian Open lead

    By The Associated Press | From Page: B1 | Gallery

    Moss powers A’s past Astros

    By The Associated Press | From Page: B1 | Gallery

     
    Enriquez brilliant, but Post 77 season ends with Area 1 loss

    By Bruce Gallaudet | From Page: B1 | Gallery

     
    The un-Armstrong? Tour ‘boss’ Nibali wins Stage 18

    By The Associated Press | From Page: B8 | Gallery

    .

    Features

    .

    Arts

    ‘A Most Wanted Man’: Superb espionage drama

    By Derrick Bang | From Page: A9 | Gallery

     
    Clyde Elmore: Art in the Wild

    By Evan Arnold-Gordon | From Page: A9 | Gallery

    Musicians perform at Sunday service

    By Enterprise staff | From Page: A17 | Gallery

     
    .

    Business

    Accord’s latest model is most fuel efficient

    By Ann M. Job | From Page: B3 | Gallery

     
     
    .

    Obituaries

    Mary Lita Bowen

    By Special to The Enterprise | From Page: A4

     
    James Thomas Feather

    By Special to The Enterprise | From Page: A4

    Richard ‘Dick’ Robenalt

    By Special to The Enterprise | From Page: A7

     
    .

    Comics

    Comics: Friday, July 25, 2014

    By Creator | From Page: A13

     
    .

    Real Estate Review

    Featured Listing

    By Zack Snow | From Page: RER1

    Professional Services Directory

    By Zack Snow | From Page: RER2

    Remax

    By Zack Snow | From Page: RER3

    Sherman Home

    By Zack Snow | From Page: RER4

    Tracy Harris

    By Zack Snow | From Page: RER4

    Vaughan Brookshaw

    By Zack Snow | From Page: RER4

    Lyon Real Estate

    By Zack Snow | From Page: RER4

    Julie Leonard

    By Zack Snow | From Page: RER5

    Ciana Wallace

    By Zack Snow | From Page: RER6

    Melrina A Maggiora

    By Zack Snow | From Page: RER7

    Joe Kaplan

    By Zack Snow | From Page: RER7

    Jo Vallejo

    By Zack Snow | From Page: RER8

    Karen Waggoner

    By Zack Snow | From Page: RER9

    Jamie Madison

    By Zack Snow | From Page: RER9

    Malek Baroody

    By Zack Snow | From Page: RER10

    Carol Coder

    By Zack Snow | From Page: RER11

    Diane Lardelli

    By Zack Snow | From Page: RER11

    Jason Sull

    By Zack Snow | From Page: RER11

    Coldwell Banker

    By Zack Snow | From Page: RER12

    Coldwell Banker

    By Zack Snow | From Page: RER13

    Julie Partain

    By Zack Snow | From Page: RER14

    Lisa Haass

    By Zack Snow | From Page: RER14

    Leslie Blevins

    By Zack Snow | From Page: RER14

    Yolo FCU

    By Zack Snow | From Page: RER15

    David Campos

    By Zack Snow | From Page: RER16

    Heather Barnes

    By Zack Snow | From Page: RER16

    Willowbank Park

    By Zack Snow | From Page: RER16

    Kim Eichorn

    By Zack Snow | From Page: RER17

    Dana Hawkins & Caitlin McCalla

    By Zack Snow | From Page: RER18

    Dana Hawkins & Caitlin McCalla

    By Zack Snow | From Page: RER18

    Susan von Geldern

    By Zack Snow | From Page: RER19

    Open House Map

    By jboydston | From Page: RER19

    Chris Snow

    By Zack Snow | From Page: RER19

    Travis Credit Union

    By Zack Snow | From Page: RER20

    Patricia Echevarria

    By Zack Snow | From Page: RER21

    Lynne Wegner

    By Zack Snow | From Page: RER21

    Kim Merrel Lamb

    By Zack Snow | From Page: RER21

    Martha Bernauer

    By Zack Snow | From Page: RER21

    Open House Map

    By Special to The Enterprise | From Page: RER23

    F1rst Street Real Estate

    By Zack Snow | From Page: RER24