Friday, October 31, 2014
YOLO COUNTY NEWS
99 CENTS

Researchers sound cancer warning on stem cell therapy

By
From page A4 | October 04, 2012 |

UC Davis researchers are urging caution after discovering new evidence that shows a type of stem cell being considered for disease therapies is similar to cells that cause cancer.

In a new article in the journal Stem Cells and Development, the researchers say that although the stem cells, called induced pluripotent stem cells, show promise as a way to treat injuries, disease and chronic conditions, they could also cause malignant cancer.

“It means that much more study is required before iPSCs can be used clinically,”  said Paul Knoepfler, associate professor of cell biology and human anatomy, and principal investigator of the study, in a UCD news release. “However, our study adds to a growing knowledge base that not only will help make stem cell therapies safer, but also provide us with new understandings about the cancer-causing process and more effective ways to fight the disease.”

The UCD study shows both iPSCs and embryonic stems cells showed “significant similarities” to malignant sarcoma cancer cells, according to the news release. The researchers found that genes that were not expressed in iPSCs were also not expressed in the cancer-generating cells and that both cell types showed evidence of similar metabolic activities.

Like embryonic stem cells, iPSCs can become any cell type — making them appealing because they sidestep the controversy over the use embryonic stem cells. The iPSCs can be taken from a patient’s skin and can be induced to produce needed tissues, eliminating the need for a patient to take immunosuppressive drugs after receiving a donor transplant.

Knoepfler said that iPSCs should be used to create cells or tissues in the laboratory, rather than be transplanted directly into a patient, thereby reducing the risk of tumor development as a side effect. Even trace amounts of iPSCs could cause cancer, he warned.

The researchers did find differences between iPSCs and cancer cells that may pave the way for making iPSCs safer.

In fact, they were able to tranfsorm tumor-generating cells into cells similar to iPS by manipulating their genetic makeup — suggesting that cancer cells could be reprogrammed, turning tumors into normal stem cells, Knoepfler said.

Other study authors are John Riggs, Bonnie Barrilleaux, Natalia Varlakhanova, Kelly Bush and Vanessa Chan, all of the department of cell biology and human anatomy. The the California Institute for Regenerative Medicine and from the National Institutes of Health funded their work.

Comments

comments

Cory Golden

Cory Golden

The Enterprise's higher-education and congressional reporter. http://about.me/cory_golden
.

News

Gardner guilty of murder, with special circumstances

By Lauren Keene | From Page: A1 | Gallery

 
State superintendent makes campaign stop in Davis

By Jeff Hudson | From Page: A1 | Gallery

 
State races test one-party rule

By New York Times News Service | From Page: A2

Meet Poppenga at Saturday reception

By Enterprise staff | From Page: A2

 
Bob Dunning: Lawn display causes a theological crisis

By Bob Dunning | From Page: A2 | Gallery

Couple killed in Yolo County crash

By Lauren Keene | From Page: A2

 
Same-party races challenge incumbents

By The Associated Press | From Page: A2

 
Indians celebrate Diwali with gala on Sunday

By Special to The Enterprise | From Page: A3

Rairdan dinged for late report

By Jeff Hudson | From Page: A3

 
Veterans will tailgate at ‘Salute to Heroes’ game

By Enterprise staff | From Page: A3

Wolk hailed for environmental votes

By Enterprise staff | From Page: A3

 
Yamada honored for leadership on aging issues

By Enterprise staff | From Page: A3

Embroidery group meets at mall

By Enterprise staff | From Page: A3

 
Bones for Life classes offered

By Enterprise staff | From Page: A4

Bet Haverim will hear Israel update

By Special to The Enterprise | From Page: A4

 
Local artisans featured at holiday craft fair

By Enterprise staff | From Page: A4

Got bikes? Donate ‘em!

By Enterprise staff | From Page: A4

 
Kids walk for friends at Birch Lane

By Special to The Enterprise | From Page: A4

Explorit: Creep out with some spooky science

By Lisa Justice | From Page: A4

 
Shambhala offers Tai Chi class

By Special to The Enterprise | From Page: A4

Enjoy wine, music and art at Sunday fundraiser for DHS choir

By Anne Ternus-Bellamy | From Page: A9

 
.

Forum

New-school cheating on the smartphone

By Creators Syndicate | From Page: B5

 
My choices on Tuesday

By Letters to the Editor | From Page: A10

 
Garamendi, Dodd get my votes

By Letters to the Editor | From Page: A10

Tom Meyer cartoon

By Debbie Davis | From Page: A10

 
High hopes for Sunder

By Letters to the Editor | From Page: A10

Public service is in her heart

By Letters to the Editor | From Page: A10

 
A calm, thoughtful voice

By Letters to the Editor | From Page: A10

Sunder is a perfect fit

By Letters to the Editor | From Page: A10

 
Best predictor is past behavior

By Letters to the Editor | From Page: A10

Vote for students, with Tuck

By Letters to the Editor | From Page: A10

 
.

Sports

DHS plays undefeated Pacers Friday night

By Enterprise staff | From Page: B1

 
Blue Devil girls net an easy win at Grant

By Enterprise staff | From Page: B1 | Gallery

Aggie offense A-OK; now what about defense?

By Bruce Gallaudet | From Page: B1 | Gallery

 
In Davis, rugby is as American as apple pie

By Bruce Gallaudet | From Page: B1

 
 
Niemi’s 43 saves aren’t enough in loss to Wild

By The Associated Press | From Page: B8 | Gallery

.

Features

.

Arts

 
Calling all artists for upcoming show

By Enterprise staff | From Page: A11

‘Birdman': A dark comedy that soars

By Derrick Bang | From Page: A11

 
DHS Madrigals host singing workshop

By Enterprise staff | From Page: A12

 
Marcia Ball to play at The Palms

By Enterprise staff | From Page: A12 | Gallery

 
.

Business

Big, capable luxury defines Yukon

By Ann M. Job | From Page: A5 | Gallery

 
.

Obituaries

Joseph Francis Gray

By Special to The Enterprise | From Page: A4

 
.

Comics

Comics: Friday, October 31, 2014

By Creator | From Page: B6

 
.

Real Estate Review

Featured Listing

By Special to The Enterprise | From Page: RER1

Professional Services Directory

By Special to The Enterprise | From Page: RER2

Lyon Real Estate

By Special to The Enterprise | From Page: RER3

RE/Max Gold

By Special to The Enterprise | From Page: RER4

Kim Eichorn

By Special to The Enterprise | From Page: RER5

Juan Ramirez

By Special to The Enterprise | From Page: RER6

Susan von Geldern

By Special to The Enterprise | From Page: RER6

Team Traverso

By Special to The Enterprise | From Page: RER6

Yolo FCU

By Special to The Enterprise | From Page: RER6

Tracy Harris

By Special to The Enterprise | From Page: RER7

Susan von Geldern

By Special to The Enterprise | From Page: RER7

Wells Fargo Home Mortgage

By Special to The Enterprise | From Page: RER8

Julie Leonard

By Special to The Enterprise | From Page: RER8

Joe Kaplan

By Special to The Enterprise | From Page: RER9

Melrina A Maggiora

By Special to The Enterprise | From Page: RER9

Coldwell Banker

By Special to The Enterprise | From Page: RER10

Leslie Blevins

By Special to The Enterprise | From Page: RER12

Julie Partain

By Special to The Enterprise | From Page: RER12

Robin Garland

By Special to The Enterprise | From Page: RER13

Jamie Madison

By Special to The Enterprise | From Page: RER13

Diane Lardelli

By Special to The Enterprise | From Page: RER13

Karen Waggoner

By Special to The Enterprise | From Page: RER14

Jamie Madison & Associates

By Special to The Enterprise | From Page: RER14

Lisa Haass

By Special to The Enterprise | From Page: RER14

Ciana Wallace

By Special to The Enterprise | From Page: RER15

Travis Credit Union

By Special to The Enterprise | From Page: RER16

Malek Baroody

By Special to The Enterprise | From Page: RER17

Marcelo Campos

By Special to The Enterprise | From Page: RER18

F1rst Street Real Estate

By Special to The Enterprise | From Page: RER20