Thursday, March 5, 2015
YOLO COUNTY NEWS
99 CENTS

Researchers sound cancer warning on stem cell therapy

By
From page A4 | October 04, 2012 |

UC Davis researchers are urging caution after discovering new evidence that shows a type of stem cell being considered for disease therapies is similar to cells that cause cancer.

In a new article in the journal Stem Cells and Development, the researchers say that although the stem cells, called induced pluripotent stem cells, show promise as a way to treat injuries, disease and chronic conditions, they could also cause malignant cancer.

“It means that much more study is required before iPSCs can be used clinically,”  said Paul Knoepfler, associate professor of cell biology and human anatomy, and principal investigator of the study, in a UCD news release. “However, our study adds to a growing knowledge base that not only will help make stem cell therapies safer, but also provide us with new understandings about the cancer-causing process and more effective ways to fight the disease.”

The UCD study shows both iPSCs and embryonic stems cells showed “significant similarities” to malignant sarcoma cancer cells, according to the news release. The researchers found that genes that were not expressed in iPSCs were also not expressed in the cancer-generating cells and that both cell types showed evidence of similar metabolic activities.

Like embryonic stem cells, iPSCs can become any cell type — making them appealing because they sidestep the controversy over the use embryonic stem cells. The iPSCs can be taken from a patient’s skin and can be induced to produce needed tissues, eliminating the need for a patient to take immunosuppressive drugs after receiving a donor transplant.

Knoepfler said that iPSCs should be used to create cells or tissues in the laboratory, rather than be transplanted directly into a patient, thereby reducing the risk of tumor development as a side effect. Even trace amounts of iPSCs could cause cancer, he warned.

The researchers did find differences between iPSCs and cancer cells that may pave the way for making iPSCs safer.

In fact, they were able to tranfsorm tumor-generating cells into cells similar to iPS by manipulating their genetic makeup — suggesting that cancer cells could be reprogrammed, turning tumors into normal stem cells, Knoepfler said.

Other study authors are John Riggs, Bonnie Barrilleaux, Natalia Varlakhanova, Kelly Bush and Vanessa Chan, all of the department of cell biology and human anatomy. The the California Institute for Regenerative Medicine and from the National Institutes of Health funded their work.

Comments

comments

Cory Golden

Cory Golden

The Enterprise's higher-education and congressional reporter. http://about.me/cory_golden
  • Recent Posts

  • Enter your email address to subscribe to this newspaper and receive notifications of new articles by email.

  • .

    News

    Mother pleads not guilty to lesser charges in baby’s death

    By Lauren Keene | From Page: A1 | Gallery

     
    ‘The Liar’ will have audiences in stitches

    By Anne Ternus-Bellamy | From Page: A1 | Gallery

     
    Hibbert Lumber honored as an Owl Wise Leader

    By Felicia Alvarez | From Page: A1 | Gallery

     
    Bob Dunning: Is there a fair way out of this?

    By Bob Dunning | From Page: A2

    Speaker will illuminate universe’s dark side

    By Enterprise staff | From Page: A3

     
    Fiesta dinner, auction benefit Chávez School

    By Enterprise staff | From Page: A3

     
    World Language Fair brings nations to Davis

    By Krystal Lau | From Page: A3

    Get crackin’ for Yolo Crisis Nursery

    By Enterprise staff | From Page: A3

     
    Taizé service set Friday at DCC

    By Enterprise staff | From Page: A3

    Climate Lobby will meet March 11

    By Enterprise staff | From Page: A3

     
    Be featured in Woodland’s water-wise landscape tour

    By Enterprise staff | From Page: A3

    UFC speaker series gives ‘A Winemaker’s Journey’

    By Enterprise staff | From Page: A3

     
    Divorce options covered in Saturday workshop

    By Special to The Enterprise | From Page: A4

    Author events coming up at The Avid Reader

    By Enterprise staff | From Page: A5

     
    Community forum with police will address hate in Davis

    By Enterprise staff | From Page: A5

    .

    Forum

    Vernal pools are in danger

    By Letters to the Editor | From Page: A6

     
    Migratory waterfowl threatened

    By Letters to the Editor | From Page: A6

    Dog in shopping cart concerning

    By Letters to the Editor | From Page: A6

     
    Drought stresses California’s trees

    By Letters to the Editor | From Page: A6

    Initiative carnival coming next year

    By Tom Elias | From Page: A6

     
    Tom Meyer cartoon

    By Debbie Davis | From Page: A6

    Hunting has many benefits

    By Letters to the Editor | From Page: A6

     
    This river needs our help

    By Letters to the Editor | From Page: A6

    .

    Sports

    DHS boys track team has high aspirations

    By Dylan Lee | From Page: B1 | Gallery

     
    Blue Devil boys mash Marauders

    By Evan Ream | From Page: B1 | Gallery

    Devils’ big inning is the difference in baseball opener

    By Bruce Gallaudet | From Page: B1 | Gallery

     
    DHS golfers dominate Elk Grove

    By Enterprise staff | From Page: B1

    Davis softball offense explodes for first win

    By Chris Saur | From Page: B1 | Gallery

     
    Youth roundup: U15 Knights rout El Dorado Hills

    By Enterprise staff | From Page: B3 | Gallery

    Youth soccer: Barker lights it up for Blue Thunder

    By Enterprise staff | From Page: B3 | Gallery

     
    Sports briefs: DHS swimmers speed past Herd

    By Enterprise staff | From Page: B8

    .

    Features

    DHS sophomore honored for volunteerism

    By Anne Ternus-Bellamy | From Page: A5

     
    .

    Arts

    ‘Witness for the Prosecution’ to be screened Sunday

    By Special to The Enterprise | From Page: A7

     
    Hear EZ Street Saturday at winery

    By Enterprise staff | From Page: A7

     
    UC Davis bands perform on March 11

    By Jeff Hudson | From Page: A7

     
    Wealth of Nations plays Saturday

    By Special to The Enterprise | From Page: A7

     
    Resler releases memoir, ‘The Last Protégée’

    By Enterprise staff | From Page: A8

    Athens Guitar Duo to perform at Davis Arts Center

    By Special to The Enterprise | From Page: A8

     
    .

    Business

    .

    Obituaries

    .

    Comics

    Comics: Thursday, March 5, 2015

    By Creator | From Page: B6