Thursday, March 5, 2015
YOLO COUNTY NEWS
99 CENTS

Scientists eye new treatments for MS

By
From page A6 | May 26, 2013 |

Working with lab mice models, UC Davis scientists have detected a novel molecular target for the design of drugs that could be safer and more effective than current FDA-approved medications against multiple sclerosis.

The findings of the research study could have therapeutic applications for MS as well as cerebral palsy and leukodystrophies, all disorders associated with loss of white matter, which is the brain tissue that carries information between nerve cells in the brain and the spinal cord.

The target, a protein referred to as mitochondrial translocator protein, or TSPO, had been previously identified but not linked to MS, an autoimmune disease that strips the protective fatty coating off nerve fibers of the brain and spinal cord.

The mitrochronical TSPO is located on the outer surface of mitochondria, cellular structures that supply energy to the cells. Damage to the fatty coating, or myelin, slows the transmission of the nerve signals that enable body movement as well as sensory and cognitive functioning.

The scientists identified mitochondrial TSPO as a potential therapeutic target when mice that had symptoms of MS improved after being treated with the anti-anxiety drug etifoxine, which interacts with mitochondrial TSPO.

When etifoxine, a drug clinically available in Europe, was administered to the MS mice before they had clinical signs of disease, the severity of the disease was reduced when compared to the untreated lab animals. When treated at the peak of disease severity, the animals’ MS symptoms improved.

The findings of the UC Davis research team, led by principal investigator Wenbin Deng, associate professor of biochemistry and molecular medicine, were published last week in the journal EMBO Molecular Medicine. The other co-authors of the paper are Daniel Daugherty, Vimal Selvaraj, Olga Chechneva, Xiao-Bo Liu and David Pleasure.

— UC Davis Health News Service

Comments

comments

.

News

Mother pleads not guilty to lesser charges in baby’s death

By Lauren Keene | From Page: A1 | Gallery

 
‘The Liar’ will have audiences in stitches

By Anne Ternus-Bellamy | From Page: A1 | Gallery

 
Hibbert Lumber honored as an Owl Wise Leader

By Felicia Alvarez | From Page: A1 | Gallery

 
Bob Dunning: Is there a fair way out of this?

By Bob Dunning | From Page: A2

Boots help dogs deal with cold

By The Associated Press | From Page: A2 | Gallery

 
High court hears Obamacare arguments

By The Associated Press | From Page: A2

Fiesta dinner, auction benefit Chávez School

By Enterprise staff | From Page: A3

 
World Language Fair brings nations to Davis

By Krystal Lau | From Page: A3

Get crackin’ for Yolo Crisis Nursery

By Enterprise staff | From Page: A3

 
Taizé service set Friday at DCC

By Enterprise staff | From Page: A3

Climate Lobby will meet March 11

By Enterprise staff | From Page: A3

 
Be featured in Woodland’s water-wise landscape tour

By Enterprise staff | From Page: A3

UFC speaker series gives ‘A Winemaker’s Journey’

By Enterprise staff | From Page: A3

 
Speaker will illuminate universe’s dark side

By Enterprise staff | From Page: A3

 
Divorce options covered in Saturday workshop

By Special to The Enterprise | From Page: A4

Author events coming up at The Avid Reader

By Enterprise staff | From Page: A5

 
Community forum with police will address hate in Davis

By Enterprise staff | From Page: A5

.

Forum

No real reason to stay

By Creators Syndicate | From Page: B5

 
Migratory waterfowl threatened

By Letters to the Editor | From Page: A6

Dog in shopping cart concerning

By Letters to the Editor | From Page: A6

 
Drought stresses California’s trees

By Letters to the Editor | From Page: A6

Tom Meyer cartoon

By Debbie Davis | From Page: A6

 
Initiative carnival coming next year

By Tom Elias | From Page: A6

Hunting has many benefits

By Letters to the Editor | From Page: A6

 
This river needs our help

By Letters to the Editor | From Page: A6

Vernal pools are in danger

By Letters to the Editor | From Page: A6

 
.

Sports

DHS boys track team has high aspirations

By Dylan Lee | From Page: B1 | Gallery

 
Blue Devil boys mash Marauders

By Evan Ream | From Page: B1 | Gallery

Devils’ big inning is the difference in baseball opener

By Bruce Gallaudet | From Page: B1 | Gallery

 
DHS golfers dominate Elk Grove

By Enterprise staff | From Page: B1

Davis softball offense explodes for first win

By Chris Saur | From Page: B1 | Gallery

 
San Antonio enjoys home cooking to rout Sacramento

By The Associated Press | From Page: B3

Youth roundup: U15 Knights rout El Dorado Hills

By Enterprise staff | From Page: B3 | Gallery

 
Youth soccer: Barker lights it up for Blue Thunder

By Enterprise staff | From Page: B3 | Gallery

Sports briefs: DHS swimmers speed past Herd

By Enterprise staff | From Page: B8

 
.

Features

DHS sophomore honored for volunteerism

By Anne Ternus-Bellamy | From Page: A5

 
.

Arts

Hear EZ Street Saturday at winery

By Enterprise staff | From Page: A7

 
UC Davis bands perform on March 11

By Jeff Hudson | From Page: A7

 
Wealth of Nations plays Saturday

By Special to The Enterprise | From Page: A7

‘Witness for the Prosecution’ to be screened Sunday

By Special to The Enterprise | From Page: A7

 
 
Resler releases memoir, ‘The Last Protégée’

By Enterprise staff | From Page: A8

Athens Guitar Duo to perform at Davis Arts Center

By Special to The Enterprise | From Page: A8

 
.

Business

.

Obituaries

.

Comics

Comics: Thursday, March 5, 2015

By Creator | From Page: B6