Sunday, January 25, 2015
YOLO COUNTY NEWS
99 CENTS

Study: Fatty acid in fish oil shows promise against cancer

By
From page A3 | April 07, 2013 |

UC Davis and Harvard University scientists have found that a product resulting from a metabolized omega-3 fatty acid helps combat cancer by cutting off the supply of oxygen and nutrients that fuel tumor growth and spread of the disease.

Their work, in the Proceedings of the National Academy of Sciences, provides the first scientific evidence of the anti-cancer, anti-metastatic effects of the metabolite epoxy docosapentaenoic acid (EDP).

EDP is an endogenous compound produced by the human body from the omega-3 fatty acid docosahexaenoic acid (DHA) found in fish oil and breast milk.

In animal studies, the scientists found that EDP inhibits angiogenesis: the formation of new blood vessels in the body.

Tumors grow and spread by hijacking the normal biological process of angiogenesis, which plays a role in wound repair as well in growth and development.

By inhibiting angiogenesis, EDP reduces the growth and spread (metastasis) of tumors in mice, the researchers found.

EDP works by a different mechanism than many current anti-cancer drugs that block angiogenesis.

The researchers said that future studies hopefully will determine that stabilized EDP can be safely and effectively combined with other current anti-angiogenesis drugs in the treatment of cancer.

“As far as we know, EDPs are the first signaling lipids that have been discovered to have such potent anti-cancer effects,” said Guodong Zhang, the lead author of the article and a postdoctoral researcher in the laboratory of Bruce Hammock in the department of entomology and the UCD Comprehensive Cancer Center.

“The study by Zhang and colleagues has uncovered a previously unrecognized anti-cancer effect of omega-3 fatty acids, which are an important lipid component of diets that have been developed to prevent heart disease and cancer,” said Jonathan Lindner, professor of medicine at Oregon Health and Sciences University.

“The authors have demonstrated that metabolites of these lipids can act to suppress the growth of new blood vessels that are necessary to feed tumor growth,” added Lindner, who was not involved in the study. “By shutting off a tumor’s blood supply, these compounds can act to dramatically slow tumor growth and prevent spread.

“The results from this study suggest that new drug strategies for fighting cancer could emerge from knowledge of how the body uses nutrition to promote health.”

The EDPs are broken down in the body by inhibiting the enzyme soluble epoxide hydrolase (sHI). In previous research, Hammock’s lab showed that inhibitors of the sEHI enzyme help to normalize physiological activity.

In the current study, the researchers determined that the addition of sEHI stabilized EDP in circulating blood, thereby producing anti-tumor effects.

The anti-cancer drugs sorafenib and regorafenib are FDA-approved sEHIs.

“It may be possible to improve the efficacy of these anti-cancer drugs by combining them with a diet high in omega-3 and low in omega-6 fatty acids,” Hammock said.

The researchers also found that a metabolite of arachidonic acid (ARA), an omega-6 fatty acid, has the opposite effect of EDP. The ARA metabolite, epoxyeicosatrienoic acids (EETs), slightly increases angiogenesis and tumor progression in mice.

“There is no free lunch,” said Katherine Ferrara, professor in the UCD department of biomedical engineering. “The EETs encourage wound healing, while the EDPs block the growth and metastasis of solid tumors.”

The scientists determined that EDP starves tumors by inhibiting vascular endothelial growth factor (VEGF) and fibroblast growth factor-2 (FGF-2)-induced angiogenesis in mice. In laboratory cultures, EDP also suppresses the endothelial cell migration needed for new blood vessels.

Thus, EDP-based angiogenesis inhibitors offer an advantage over drugs that target the VEGF-VEGFR2 pathway, which increase patients’ risk for high blood pressure.

Because EDPs widen the blood vessels, a medication based on the new discovery should not increase the patient’s risk for high blood pressure.

— UC Davis Health News Office

Comments

comments

Dorsey Griffith

  • Recent Posts

  • Enter your email address to subscribe to this newspaper and receive notifications of new articles by email.

  • .

    News

    Bridges of Yolo County: Wear, tear … repair?

    By Elizabeth Case | From Page: A1 | Gallery

     
    Four days of unusual, adventuresome music

    By Jeff Hudson | From Page: A1 | Gallery

     
    Spanish police arrest 4 suspected members of a jihadi cell

    By The Associated Press | From Page: A2

    Rockets kill 30 in Ukrainian city as rebels launch offensive

    By The Associated Press | From Page: A2

     
    Abe ‘speechless’ after video claims IS hostage dead

    By The Associated Press | From Page: A2

    GOP presses state bills limiting gay rights before ruling

    By The Associated Press | From Page: A2

     
    Abortion opponents express renewed hope at California rally

    By The Associated Press | From Page: A2

     
    Share your love (story) with us

    By Enterprise staff | From Page: A3

    Sip wines at St. James’ annual tasting

    By Special to The Enterprise | From Page: A3

     
    Fake schools draw federal scrutiny

    By The Associated Press | From Page: A3 | Gallery

    Winter produce available at Sutter market

    By Special to The Enterprise | From Page: A3

     
    Vote for your favorites in Readers’ Choice poll

    By Enterprise staff | From Page: A3

    Donations to be distributed during homeless count

    By Anne Ternus-Bellamy | From Page: A4

     
    Speaker will share computer security tips

    By Enterprise staff | From Page: A4

    Logos Books celebrates 5 years, offers language groups

    By Enterprise staff | From Page: A4

     
    Australian olive oil company opens U.S. headquarters in Woodland

    By Special to The Enterprise | From Page: A4

    Explore at the YOLO Outdoor Expo

    By Enterprise staff | From Page: A4

     
    Pedal around Davis on weekly bike ride

    By Enterprise staff | From Page: A4

     
    Yolo animal shelter seeking rawhide donations

    By Lauren Keene | From Page: A5

    Woodland Healthcare employees take Great Kindness Challenge

    By Special to The Enterprise | From Page: A5

     
    At the Pond: Nest boxes give birds new homes

    By Jean Jackman | From Page: A6 | Gallery

    California ranks worst in nation for guidance counselors

    By The Associated Press | From Page: A7

     
    Words and Music Festival events

    By Jeff Hudson | From Page: A12

    Davis, Woodland are saving water

    By Elizabeth Case | From Page: A12

     
    .

    Forum

    Family isn’t keen on relationship

    By Creators Syndicate | From Page: A8

     
     
    Caring for the aging mouth

    By Samer Alassaad | From Page: A8

    Rick McKee cartoon

    By Debbie Davis | From Page: A10

     
    Big utilities’ nightmare begins to play out

    By Tom Elias | From Page: A10

    Mayor’s Corner: Let’s renew Davis together

    By Dan Wolk | From Page: A10

     
    We have the right to choose

    By Letters to the Editor | From Page: A10

    We don’t have to suffer

    By Letters to the Editor | From Page: A10

     
    City helped immensely

    By Letters to the Editor | From Page: A10

    When measles spreads from Disneyland, it’s a small world after all

    By New York Times News Service | From Page: A11

     
    From innovation parks to innovative buildings and planning

    By Special to The Enterprise | From Page: A11

    .

    Sports

    Wildcats’ inaugural kids development league exceeds expectations

    By Bruce Gallaudet | From Page: B1 | Gallery

     
    Aggies get top 2015 gymnastics score, but fall short

    By Bruce Gallaudet | From Page: B1 | Gallery

    Loud crowd sees DHS boys win

    By Spencer Ault | From Page: B1 | Gallery

     
    Lady Devils hold off Pacers, stay perfect in league

    By Enterprise staff | From Page: B1

    UCD men take two tennis matches

    By Enterprise staff | From Page: B8

     
    Watney in ninth at Humana Challenge

    By Staff and wire reports | From Page: B8

    .

    Features

    .

    Arts

    .

    Business

    Davis man focusing on cannabidiol business

    By Will Bellamy | From Page: A9

     
    Marrone Bio’s Regalia approved for new uses in Canada

    By Special to The Enterprise | From Page: A9

     
    UCD grad makes insurance ‘hot 100′ list

    By Enterprise staff | From Page: A9

    Yolo County real estate sales

    By Zoe Juanitas | From Page: A9

     
    .

    Obituaries

    .

    Comics

    Comics: Sunday, January 25, 2015

    By Creator | From Page: B8