Wednesday, April 16, 2014
YOLO COUNTY NEWS
99 CENTS

UCD: Drug holds promise for reducing heart disease

By
From page A9 | August 02, 2013 | Leave Comment

UC Davis researchers have shown more promise in a new approach to heart disease, developing a way to block a key protein rather than targeting high blood pressure or cholesterol.

The experimental agent inhibits C-reactive protein, a biomarker of heart attacks, strokes and chest pain. Results were published online last week in the “International Journal of Cardiology.”

The researchers’ new tack is based on recent studies showing that the body’s inflammatory response is key to development of fatty deposits in blood vessels to heart attacks and strokes.

Patients whose C-reactive protein levels are high are at risk for suffering a heart attack, stroke or sudden death from cardiovascular disease — even if their blood cholesterol and blood pressure are normal, said Ishwarlal Jialal, senior author of the article and professor of pathology and laboratory medicine, in a news release.

“There is an urgent need to develop inhibitors that specifically block the biological effects of C-reactive protein,” Jialal said.

Some 15 to 20 percent of heart attacks and strokes occur in patients without well-established risk factors like high blood pressure and blood cholesterol, obesity, lack of regular exercise and cigarette smoking, according to UCD.

The immune system produces CRP to clear dead and disintegrating cells. It is usually found in the blood in trace amounts.

Jialal’s lab successfully used a synthesized peptide, a small protein molecule, to reduce inflammation caused by human CRP injected into rats. Rats’ bodies don’t normally produce the protein, but research elsewhere has shown injecting rats with human CRP increases tissue damage from heart attacks or strokes.

The UCD team has previously reduced CRP levels in cultures of human cells.

The experimental agent is the third known CRP inhibitor under development, according to UCD. Before human trials can take place, the lab plans to conduct five years worth of studies to evaluate the inhibitor’s long-term effects.

— Reach Cory Golden at cgolden@davisenterprise.net or 530-747-8046. Follow him on Twitter at @cory_golden

Cory Golden

Cory Golden

The Enterprise's higher-education and congressional reporter. http://about.me/cory_golden
LEAVE A COMMENT

Discussion | No comments

The Davis Enterprise does not necessarily condone the comments here, nor does it review every post. Read our full policy

.

News

 
Frank, Peterman, Davis Bicycles! get us from here to there

By Special to The Enterprise | From Page: A1 | Gallery

Family fiction in miniature showcased at bookstore event

By Special to The Enterprise | From Page: A3 | Gallery

 
Local professor subdues unruly man on flight

By Adrian Glass-Moore | From Page: A3

Rotarians, students, teachers, parents collaborate on planter boxes

By Enterprise staff | From Page: A4 | Gallery

 
Yolo Crisis Nursery is in crisis; please help

By Special to The Enterprise | From Page: A4

Meditation, Buddhism classes offered

By Enterprise staff | From Page: A4

 
Seniors can get tips for getting around town

By Enterprise staff | From Page: A4

School has garden plots for rent

By Enterprise staff | From Page: A4

 
Sugar overload, on ‘Davisville’

By Enterprise staff | From Page: A4

Check out the night sky

By Enterprise staff | From Page: A5 | Gallery

 
Hop to it: Easter Bunny meets Davis history tour

By Enterprise staff | From Page: A5

Garden doctor: Veggie gardening available year-round

By Special to The Enterprise | From Page: A5

 
Animal expert explains dogs’ thinking

By Special to The Enterprise | From Page: A5

Central Park Gardens to host Volunteer Orientation Day

By Enterprise staff | From Page: A7 | Gallery

 
Are we there yet?: Self-reflections of a would-be stage mom

By Tanya Perez | From Page: A8Comments are off for this post

.

Forum

Urban forest under siege

By Special to The Enterprise | From Page: A6

 
Drought care for our trees

By Letters to the Editor | From Page: A6

Tom Meyer cartoon

By Debbie Davis | From Page: A6

 
.

Sports

UCD pen allows 19 hits in Causeway rout

By Bruce Gallaudet | From Page: B1 | Gallery

 
DHS softball struggles in nonleague outing

By Spencer Ault | From Page: B1 | Gallery

Devils open Boras Classic by splitting games

By Enterprise staff | From Page: B1 | Gallery

 
 
JV/frosh roundup: DHS sweeps a trio of baseball games

By Enterprise staff | From Page: B2 | Gallery

Baseball roundup: River Cats get by Grizzlies at Raley

By The Associated Press | From Page: B3

 
Sports briefs: Stanford sends Aggies home with a lacrosse loss

By Enterprise staff | From Page: B8 | Gallery

.

Features

 
.

Arts

See Flower Power exhibit at Gallery 625

By Enterprise staff | From Page: A9 | Gallery

 
Red Union Blue inks record deal

By Landon Christensen | From Page: A9 | Gallery

Craft Center exhibit explores ‘Possibilities’

By Special to The Enterprise | From Page: A9

 
RootStock to host wine themed plein aire exhibit

By Enterprise staff | From Page: A9

The California Honeydrops to bring danceable groove to The Palms

By Enterprise staff | From Page: A9 | Gallery

 
.

Business

.

Obituaries

.

Comics

Comics: Wednesday, April 16, 2014

By Creator | From Page: B6