Sunday, November 23, 2014
YOLO COUNTY NEWS
99 CENTS

UCD: Drug holds promise for reducing heart disease

By
From page A9 | August 02, 2013 |

UC Davis researchers have shown more promise in a new approach to heart disease, developing a way to block a key protein rather than targeting high blood pressure or cholesterol.

The experimental agent inhibits C-reactive protein, a biomarker of heart attacks, strokes and chest pain. Results were published online last week in the “International Journal of Cardiology.”

The researchers’ new tack is based on recent studies showing that the body’s inflammatory response is key to development of fatty deposits in blood vessels to heart attacks and strokes.

Patients whose C-reactive protein levels are high are at risk for suffering a heart attack, stroke or sudden death from cardiovascular disease — even if their blood cholesterol and blood pressure are normal, said Ishwarlal Jialal, senior author of the article and professor of pathology and laboratory medicine, in a news release.

“There is an urgent need to develop inhibitors that specifically block the biological effects of C-reactive protein,” Jialal said.

Some 15 to 20 percent of heart attacks and strokes occur in patients without well-established risk factors like high blood pressure and blood cholesterol, obesity, lack of regular exercise and cigarette smoking, according to UCD.

The immune system produces CRP to clear dead and disintegrating cells. It is usually found in the blood in trace amounts.

Jialal’s lab successfully used a synthesized peptide, a small protein molecule, to reduce inflammation caused by human CRP injected into rats. Rats’ bodies don’t normally produce the protein, but research elsewhere has shown injecting rats with human CRP increases tissue damage from heart attacks or strokes.

The UCD team has previously reduced CRP levels in cultures of human cells.

The experimental agent is the third known CRP inhibitor under development, according to UCD. Before human trials can take place, the lab plans to conduct five years worth of studies to evaluate the inhibitor’s long-term effects.

— Reach Cory Golden at cgolden@davisenterprise.net or 530-747-8046. Follow him on Twitter at @cory_golden

Comments

comments

Cory Golden

Cory Golden

The Enterprise's higher-education and congressional reporter. http://about.me/cory_golden
.

News

Hollywood readies its big guns for the holidays

By Derrick Bang | From Page: A1 | Gallery

 
Need for local foster parents grows

By Anne Ternus-Bellamy | From Page: A1 | Gallery

 
Tactical robot decreases officer risks

By Lauren Keene | From Page: A1 | Gallery

Bob Dunning: Signs, signs, everywhere a sign

By Bob Dunning | From Page: A2

 
For the record

By Enterprise staff | From Page: A2

Berkeley, Santa Cruz students protest fee hikes

By The Associated Press | From Page: A2

 
Couple arrested on drug, firearm possession charges

By Lauren Keene | From Page: A2

Woman confronts suspicious follower

By Lauren Keene | From Page: A2

 
Auction-bound student artwork stolen in downtown heist

By Lauren Keene | From Page: A3, 1 Comment | Gallery

UCD awarded $100M to lead program to predict, prevent pandemic threats

By Special to The Enterprise | From Page: A3

 
Breakfast with Santa tickets are going fast

By Enterprise staff | From Page: A3

Bell-ringers still needed this holiday season

By Enterprise staff | From Page: A4

 
Thanksgiving feast is open to all

By Enterprise staff | From Page: A4

Workshop will answer financial aid questions

By Enterprise staff | From Page: A4

 
Probationers, parolees graduate from Yolo transitional program

By Special to The Enterprise | From Page: A4 | Gallery

 
Free boot camp, yoga fundraiser this week

By Enterprise staff | From Page: A4

Round up at the registers for Davis schools

By Enterprise staff | From Page: A5

 
Yolo Food Bank invites locals to run with the flock

By Enterprise staff | From Page: A5

Museum announces holiday schedule

By Enterprise staff | From Page: A5

 
At the Pond: Stop, look and listen

By Jean Jackman | From Page: A5 | Gallery

Project Linus seeks donations

By Enterprise staff | From Page: A6

 
Swing your partner!

By Wayne Tilcock | From Page: A6

Fairfield School enjoys a festive feast

By Special to The Enterprise | From Page: A7 | Gallery

 
Right at home: gifts you can use and use up

By The Associated Press | From Page: A8

Dec. 10 jeans drive benefits STEAC

By Anne Ternus-Bellamy | From Page: A9

 
Davis Community Church history recounted in Sunday talk

By Enterprise staff | From Page: A10 | Gallery

Open your heart

By Enterprise staff | From Page: A11

 
Bob Hope interview pulled from ‘the vault’

By Enterprise staff | From Page: A12

.

Forum

There’s only one way to fix this

By Creators Syndicate | From Page: B5

 
Rick McKee cartoon

By Debbie Davis | From Page: A14

Heartbroken over treatment of teacher

By Letters to the Editor | From Page: A14, 1 Comment

 
Google, tell me. Is my son a genius?

By Special to The Enterprise | From Page: A14

Students barking up the wrong tree

By Our View | From Page: A14

 
Daryl Cagle cartoon

By Debbie Davis | From Page: A15

Cordial political discourse: Seven years later, the thoughts resonate

By Special to The Enterprise | From Page: A15

 
Easing the stress during college application season

By Special to The Enterprise | From Page: A15

When the computer stares back

By Creators Syndicate | From Page: A16

 
How I want to be remembered

By Marion Franck | From Page: A16

 
Watch out for holiday weight gain

By Special to The Enterprise | From Page: A16

.

Sports

New, old-look helmets not enough to lift UCD footballers

By Bruce Gallaudet | From Page: B1 | Gallery

 
Late shot sinks Aggie women

By Spencer Ault | From Page: B1 | Gallery

Turnovers costly as UC Davis loses Classic, 41-30

By Bruce Gallaudet | From Page: B1 | Gallery

 
Aggie men finish off Furman

By Enterprise staff | From Page: B1

Upset-minded Lions bounce UCD from WWPA tourney

By Enterprise staff | From Page: B1

 
UCD roundup: Seniors play well in Aggie volleyball loss

By Enterprise staff | From Page: B3 | Gallery

Wire briefs: Kings get past depleted T-Wolves

By The Associated Press | From Page: B6

 
With volleyball playoff berth, DHS accomplished its 2014 goal

By Evan Ream | From Page: B6 | Gallery

.

Features

.

Arts

.

Business

 
Don’t pass up the parking gift downtown

By Wendy Weitzel | From Page: A13

Doby Fleeman: Give thanks for our innovation culture

By Doby Fleeman | From Page: A20

 
Honey, spreads showcased at open house

By Enterprise staff | From Page: A20

.

Obituaries

.

Comics

Comics: Sunday, November 23, 2014

By Creator | From Page: B8